Friday, January 19, 2007

Turns out Tylenol works by emulating pot


EQUALS

(Photos taken from Tylenol and Cannabis-seeds.com)

Or at least it activates similar chemical pathways in the brain or something. Acetaminophen is apparently a "indirect cannabino-mimetic". This article abstract (HT: Sullivan) is a bit tough to read:
In brain and spinal cord, paracetamol[i.e. Tylenol], following deacetylation to its primary amine (p-aminophenol), is conjugated with arachidonic acid to form N-arachidonoylphenolamine, a compound already known (AM404) as an endogenous cannabinoid.
It basically explains that although Tylenol/acetaminophen/paracetamol has been used for over a century, only recently have we discovered why it works. And it works like cannibis:
These findings finally explain the mechanism of action of paracetamol and the peculiarity of its effects, including the behavioral ones.
I didn't know Tylenol had any behavioral effects. Can you get stoned on Tylenol? I'm not going to try.

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