Friday, January 19, 2007

Turns out Tylenol works by emulating pot


(Photos taken from Tylenol and

Or at least it activates similar chemical pathways in the brain or something. Acetaminophen is apparently a "indirect cannabino-mimetic". This article abstract (HT: Sullivan) is a bit tough to read:
In brain and spinal cord, paracetamol[i.e. Tylenol], following deacetylation to its primary amine (p-aminophenol), is conjugated with arachidonic acid to form N-arachidonoylphenolamine, a compound already known (AM404) as an endogenous cannabinoid.
It basically explains that although Tylenol/acetaminophen/paracetamol has been used for over a century, only recently have we discovered why it works. And it works like cannibis:
These findings finally explain the mechanism of action of paracetamol and the peculiarity of its effects, including the behavioral ones.
I didn't know Tylenol had any behavioral effects. Can you get stoned on Tylenol? I'm not going to try.


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